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Adam Aguirre

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Adam Jesús Aguirre Ducler

PROFESIÓN

Médico Veterinario (1998, Universidad de Concepción, Concepción, Chile).

ESPECIALIDAD Y/O POSTGRADOS

Investigador asociado (2019, Universidad de Yale, New Haven, EE.UU.).

Postdoctorado (2017, Universidad de Yale, New Haven, EE.UU.).

Postdoctorado (2015, Pontificia Universidad Católica de Chile, Santiago, Chile).

Doctorado en Bioquímica (2011, Universidad de Chile, Santiago, Chile).

Magíster en Bioquímica (2008, Universidad de Chile, Santiago, Chile)

POSICIÓN ACTUAL

Investigador senior.

LÍNEA DE INVESTIGACIÓN

Respuesta inmune celular y humoral antígeno específico.

PALABRAS CLAVES

Cáncer, inmunología, linfocitos T, citometría de flujo.

DESCRIPCIÓN DE INTERESES

Estudio de subpoblaciones de linfocitos T CD8+ y CD4+ respondedores a antígenos de SARS-Cov2, y Linfocitos de memoria circulantes. Estudio de subpoblaciones linfocitarias en pacientes tratados con inmunoterapia anti-PD-1/PD-L1.

Publicaciones

Seroconversion and Abundance of IgG Antibodies against S1-RBD of SARS-CoV-2 and Neutralizing Activity in the Chilean Population

REVISTA:  Journal of Immunology Research

AÑO:  2021

URL: pubmed/33644235

Insights into neutralizing antibody responses in individuals exposed to SARS-CoV-2 in Chile

REVISTA: Science Advances

AÑO: 2021

URL: Pubmed/33579701

New imidoyl-indazole platinum (II) complexes as potential anticancer agents: Synthesis, evaluation of cytotoxicity, cell death and experimental-theoretical DNA interaction studies

REVISTA:  Journal of Inorganic Biochemistry

AÑO: 2017

URL: Pubmed/28648925

Synthesis of 4(3H)quinazolinimines with selective cytotoxic effect on human acute promyelocytic leukemia cells

REVISTA: Bioorganic & Medicinal Chemistry

AÑO: 2017

URL: Pubmed/28385594

High glucocorticoid levels during gestation activate the inflammasome in hippocampal oligodendrocytes of the offspring

REVISTA: Developmental Neurobiology

AÑO: 2017

PÁGINAS: 625-642

Low Gene Dosage of Cdc42 Is Not Associated with Protein Dysfunction in Patients with Colorectal Cancer

REVISTA: DNA and Cell Biology

AÑO: 2016

PÁGINAS: 819-827

Synthesis and pharmacophore modelling of 2,6,9- trisubstituted purine derivatives and their potential role as apoptosis-inducing agents in cancer cell lines

REVISTA: Molecules

AÑO: 2015

PÁGINAS: 6808-6826

Phosphorylation of Caveolin-1 on tyrosine-14 induced by ROS enhances palmitate-induced death of beta- pancreatic cells.

REVISTA: Biochim Biophys Acta

AÑO: 2015

PÁGINAS: 693-708

Regulation of hemichannels and gap junction channels by cytokines in antigen-presenting cells

REVISTA: Mediators of Inflammation

AÑO: 2014

URL: Pubmed/25301274/

Tolerogenic dendritic cells derived from donors with natural rubber latex allergy modulate allergen-specific T-cell responses and IgE production

REVISTA: PLoS One

AÑO: 2014

URL: Pubmed/24465795

Tolerogenic dendritic cells derived from donors with natural rubber latex allergy modulate allergen-specific T-cell responses and IgE production

REVISTA: Mediators of Inflammation

AÑO: 2013

URL: Pubmed/23935250

The caveolin-1 connection to cell death and survival

REVISTA: Current Molecular Medicine

AÑO: 2013

PÁGINAS: 266 – 281

FasL-triggered death of Jurkat cells requires caspase 8-induced, ATP-dependent cross-talk between Fas and the purinergic receptor P2X(7)

REVISTA: Journal of Cellular Physiology

AÑO: 2013

PÁGINAS: 485 – 493

Biomimetic, mild chemical synthesis of CdTe-GSH quantum dots with improved biocompatibility

REVISTA: PLoS One

AÑO: 2012

URL: Pubmed/22292028

Chromosomal instability in mouse embryonic fibroblasts null for the transcriptional co-repressor Ski

REVISTA: Journal of Cellular Physiology

AÑO: 2012

PÁGINAS: 278 – 287

Infection of human monocyte-derived dendritic cells by ANDES Hantavirus enhances pro-inflammatory state, the secretion of active MMP-9 and indirectly enhances endothelial permeability

REVISTA: Journal of Cellular Physiology

AÑO: 2011

URL: Pubmed/21569520

Modulation of established murine collagen-induced arthritis by a single inoculation of short-term lipopolysaccharide-stimulated dendritic cells.

REVISTA: Annals of Rheumatic Diseases

AÑO: 2008

URL: Pubmed/18056756

Dendritic cells immunizations combine with low doses interleukin-2 induce immune responses in melanoma patients

REVISTA: Clinical and Experimental Immunology

AÑO: 2005

URL: Pubmed/16297169

Emergent therapies for Rheumatoid Arthritis

REVISTA: Revista Médica de Chile

AÑO: 2005

URL: Pubmed/16163436

The -308 polymorphism in the promoter region of the tumor necrosis factor-alpha (TNF-alpha) gene and ex vivo lipopolysaccharide-induced TNF-alpha expression in patients with aggressive periodontitis and/or type 1 diabetes mellitus

REVISTA: European Cytokine Network

AÑO: 2004

URL: Pubmed/15627647

Tumour necrosis factor-alpha (TNF-alpha) levels and influence of -308 TNF-alpha promoter polymorphism on the responsiveness to infliximab in patients with rheumatoid arthritis

REVISTA: Scandinavian Journal of Rheumatology

AÑO: 2004

URL: Pubmed/15370717

A synthetic peptide homologous to functional domain of human IL-10 down-regulates expression of MHC class I and transporter associated with antigen processing 1/2 in human melanoma cells

REVISTA: Journal of Immunology

AÑO: 2004

URL: Pubmed/15265902

An anti-human recombinant tumor necrosis factor (TNF) monoclonal antibody recognizes an epitope in feline TNF

REVISTA: Veterinary Research

AÑO: 2003

URL: Pubmed/12657209

Ex vivo lipopolysaccharide (LPS) induced TNF, IL-1, IL-6 and PGE2 secretion in whole blood from type 1 diabetes mellitus patients with or without aggressive periodontitis

REVISTA: European Cytokine Network

AÑO: 2003

URL: Pubmed/14656685

The -308 polymorphism in the tumour necrosis factor (TNF) gene promoter region and ex vivo lipopolysaccharide-induced TNF expression and cytotoxic activity in Chilean patients with rheumatoid arthritis

REVISTA: Rheumatology

AÑO: 2003

URL: Pubmed/12595628

Tissue distribution and differencial expresion of melanocortin 1 receptor, a malignant melanoma marker

REVISTA: British Journal of Cancer

AÑO: 2002

URL: Pubmed/12177778

Evaluation of tumor necrosis factor alpha production in ex vivo short term cultured whole blood from women with polycystic ovary syndrome

REVISTA: European Cytokine Network

AÑO: 2002

URL: Pubmed/12517726

Genetic polymorphism at position-308 in the promoter region of the tumor necrosis factor (TNF): implications of its allelic distribution on susceptibility or resistance to diseases in the Chilean population

REVISTA: Biological Research

AÑO: 2001

URL: Pubmed/11715861

Daily production of human tumor necrosis factor in lipopolysaccharide (LPS)-stimulated ex vivo blood culture assays.

REVISTA: European Cytokine Network

AÑO: 2001

URL: Pubmed/11282553

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